1000 Times More Potent at Activating Sirtuins than Resveratrol

1000 Times More Potent at Activating Sirtuins than Resveratrol

Resveratrol, a compound found in red grapes, activates sirtuins, our anti-ageing genes, because it mimics the free fatty acids our bodies produce when we fast and break down fat. And the free fatty acids are actually more potent sirtuin activators than resveratrol.
Besides fasting, you can also add some monounsaturated fats into your diet. You can do this with olive oil that is 78% monounsaturated fat, or avocados which have oil that is 70% monounsaturated fat.

So, keep on intermittent fasting and add some oilve oil or avocados into your diet.

But, as always, ask your health practitioner before making any changes to your lifestyle and diet.

Link to the article showing that resveratrol works as an imitation of free fatty acids (especially oleic acid, 18:1) when it comes to activating sirtuins:
Najt et al., Lipid Droplet-Derived Monounsaturated Fatty Acids Traffic via PLIN5 to Allosterically Activate SIRT1, Molecular Cell (2019),

Watch Dr. David Sinclair talk about this study and the fact that the monounsaturated fats are 1000 times more potent than resveratrol at activating sirtuins:

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